Perhaps a Quest Giver in a Local Town can help you have mercy by dropping hints of a “Legendary Cure-All.” While you’re at it, maybe the local Tavern Owner can show your PCs the Posted Bounties. They can even enlist some Local Heroes or Guildmates to help with that pesky Cursed Item.
In Carolyn Creek, some folks have become afflicted by a mysterious malady known only as “The Pox.”
It afflicts young and old alike, causing boils and pustules to form on their skin. The townspeople are used to this disformity and seem to manage just fine.
Upon further research the party uncovered that a beautiful and fragrant herb that grows along the river bed produces spores in the spring that cause mild irritation on contact.
Even after washing, the spores have already taken hold. It can take up to a month to start forming a rash, and sometimes up to 2 months to form the related pustules and boils, long after everyone has forgotten about their contact with the herb.
Lesser Restoration can cure.